Evaluation of potential antimicrobial chlorhexidine digluconate microencapsulated in model experimental dental biofilm

Background The formation of biofilm on the tooth surface is a result of the process of colonization of cariogenic bacteria, especially Streptococcus mutans, the main responsible for cariogenic (acid production) of dental biofilms [1]. The removal and chemical control of dental biofilm with chlorhexidine digluconate 0.12% (CLX) has been the most effective antimicrobial agent of choice clinic. However, despite its indisputable efficacy, no side effects such as darkening of the teeth, tongue and restorations, burning mouth and changes in taste. The formation of inclusion compounds CLX for the controlled release of the compound in a lower concentration could be a viable strategy to reduce these side effects without diminishing the therapeutic efficacy of the product [2,3]. Against this background, this study aimed to prepare nanocapsules CLX (processing aid) (1.2%) in model spray drying using modified starch as the encapsulating agent, tested in biofilm model using bovine teeth.